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Chemiluminescent Solution（General Items）
Series	Product Name	Product Name
Skeletal Metabolic	25-OH-VitaminD	25-OH-VitaminD
	Parathyroid Hormone	PTH
	Human Growth Hormone	hGH
	N-terminal Osteocalcin	N-MID
	total Type 1 Collagen Amino-terminal Lengthening Peptide	tP1NP
	Bone-specific Alkaline Phosphatase	BAP
	Type I Collagen Cross-linked C-terminal Peptide	β-CTx

Markers of bone metabolism can be divided into two categories, one is bone formation markers and the other is bone absorption markers. Bone formation markers mainly include n-terminal osteocalcin (N-MID), bone-specific alkaline phosphatase (BAP) and total type 1 collagen amino-terminal lengthening-peptide (TPINP). Bone resorption markers mainly include type I collagen cross-linked C-terminal peptide (β -CTX). N-MID is a specific non-collagenous bone matrix protein synthesized and secreted by osteoblasts in non-proliferating stage. It is composed of 49 amino acids and belongs to non-collagenous acidic glycoprotein. It is a vitamin K-dependent calcium binding protein and a specific biochemical indicator reflecting bone formation. BAP is an extracellular enzyme of osteoblasts. Its main role is to hydrolyze phosphatase in the process of osteogenesis to provide phosphoric acid for the deposition of hydroxyapatite, and hydrolyze pyrophosphate to remove its inhibition on the formation of bone salts, which is conducive to osteogenesis. BAP is involved in bone formation and is stable in serum, which is a marker of osteoblast maturation and activity. Serum BAP quantitative measurement and dynamic observation can be used as an effective parameter to monitor the changes of bone formation, and it is the most accurate marker of bone formation. Type I collagen is the most abundant type of collagen in human body, accounting for about 35% of the backbone weight and 90% of bone. Type ⅰ collagen is derived from type I procollagen. The carboxyl terminal additional peptide of procollagen removed by endopeptidase is called type I procollagen carboxyl terminal peptide (PICP), and the amino terminal additional peptide is called type I procollagen amino terminal peptide (PINP).The content of PINP in serum reflects the ability of osteoblasts to synthesize collagen and is used to monitor the indicators of osteoblast activity and bone formation. β -CTX is the most widely used marker of collagen degradation, which has good structural stability and reflects the bone resorptive activity of osteoclasts. Detection of serum CTX level can predict the severity of abnormal bone turnover and serve as an important reference index for clinical evaluation of bone turnover related diseases.

Skeletal Metabolic Chemiluminescense Immunoassay Kit

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