Cardiac Marker Chemiluminescense Immunoassay Kit

Cardiac markers are mainly used to diagnose myocardial cell injury. cTnI and cTnT play a major role in regulating cardiac striated muscle contraction and are specific and sensitive markers of myocardial injury. Lipoprotein-associated phospholipase A2(LP-PLA2) is a vascular-specific marker of inflammation. Cardiac type fatty acid binding protein (H-FABP) is a key fatty acid carrier protein, which is  the most promising marker of myocardial injury.
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Products Details

Clinical Chemistry Solution

Series

Product Name

Abbr

Cardiac Markers

L-Lactate Dehydrogenase

LDH

α-Hydroxybutyrate Dehydrogenase

α-HBDH

Creatine Kinase

CK

Creatine Kinase Isoenzyme-MB

CK-MB

Lactate Dehydrogenase Isoenzyme-1

LDH1

Heart Fatty Acid Binding Protein

H-FABP
Myocardial enzyme spectrum is one kind of blood biochemical examination, which is often used in clinical diagnosis of myocarditis and acute myocardial infarction. The indexes related to myocardial enzyme profile include lactate dehydrogenase, α -hydroxybutyrate dehydrogenase, creatine kinase, creatine kinase isoenzyme MB, lactate dehydrogenase isoenzyme 1. In addition, cardiac fatty acid binding protein is also related to cardiac muscle. Lactate dehydrogenase is a cytoplasmic enzyme widely distributed in various tissues, especially in the heart, liver, muscle and kidney. LDH in serum can be divided into five different isoenzymes by electrophoresis. Elevated LDH is common in myocardial infarction, hepatitis and pulmonary infarction. At present, it is often used for clinical auxiliary diagnosis of myocardial infarction and liver disease. Serum α-HBDH/LDH ratio can sometimes be used to distinguish heart disease from liver disease. The ratio is higher for heart disease and lower for liver disease. In addition, serum HBDH increases in hemolytic anemia. Creatine kinase mainly exists in skeletal muscle and myocardium and is one of the commonly used myocardial enzymes in clinic. Its elevation is common in acute myocardial infarction, viral myocarditis, progressive muscular atrophy, cerebrovascular accident, meningitis, low grade A patients. The specificity of CK in the auxiliary diagnosis of myocardial infarction was higher than AST and LDH. Creatine kinase consists of two subunits M and B to form three dimers - CK-BB, CK-MB, and CK-MM. CK-MB mainly exists in the myocardium, so it is clinically recognized as an important indicator for the diagnosis of myocardial infarction and the determination of myocardial necrosis, and is one of the important clinical myocardial enzyme spectrum indicators. LDH1, LDH2, LDH3, LDH4 and LDH5 are the most isozyme forms of lactate dehydrogenase in human myocardium, kidney and red blood cell, LDH1 and LDH2 are increased, and LDH1/LDH2>1 is seen in acute myocardial infarction, hemolytic anemia and other diseases. Cardiac fatty acid binding protein is a new type of small cytoplasmic protein abundant in the heart. It is highly heart-specific, but is also expressed at low concentrations in tissues other than the heart. HFABP may be detected in the blood as early as 1 to 3 hours after the onset of chest pain, peak at 6 to 8 hours and return to normal plasma levels within 24 to 30 hours after the onset of myocardial ischemic injury. Cardiac fatty acid binding cytoplasmic protein is composed of 132 amino acids and has a molecular weight of 15 kDa.

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