Factory-Made ANA Test Kit For Accurate Autoimmune Disorder Detection

Chemiluminescent Solution（Autoimmune Diseases）
Series	Product Name	Abbr
Antinuclear Antibody（ANA）	Anti-ribonucleoprotein Antibody	nRNP/Sm
	Anti-sm Antibody	Sm
	Anti-Sjögren's Syndrome Antigen A Antibody	SS-A
	Anti-Sjögren's Syndrome Antigen B Antibody	SS-B/La
	Anti-Ribosomal Protein P0 Antibody	P0
	Anti-Histone Antibody	His
	Anti-Nucleosome Antibody	Nuc
	Anti-Double-Stranded DNA Antibody	dsDNA
	Anti-Proliferating Cell Nuclear Antigen Antibody	PCNA
	Anti-Scl-70 Antibody	Scl-70
	Anti-PM-Scl Antibody	PM-Scl
	Anti-Histaminoacyl tRNA Synthetase Antibody	Jo-1
	Anti-Mitochondrial-M2 Antibody	AMA-M2
	Anti-Centromere Protein B Antibody	CENP-B
	Anti-Ro52 Antibody	Ro52
	Anti-Single-Stranded DNA Antibody	ssDNA
	Anti-Nuclear Antibody Screening	ANA

Antinuclear antibodies (ANA) are found in a variety of autoimmune and rheumatic diseases. dsDNA antibodyies is highly specific for SLE, with a positive rate of 40-90%. Anti-sm antibody is with about 5-30% positive rate for SLE. Anti-nucleosome antibody is commonly detected in SLE (50-100%) and autoimmune hepatitis (40-50%). Anti-nucleosome antibody can exist independently of anti-dsDNA antibody for which 18% of SLE patients' serum only react with nuc but not with dsDNA. Anti-histone antibody is more common (95% positive) in SLE induced by drugs such as procainamide, hydrazine or other drugs. Or it happens in 30-70% of disseminated lupus and 15-50% of patients with rheumatoid arthritis. Anti-ribosomal P0 can be detected in 10-20% of SLE patients and is found to be associated with complications of central nervous system, kidney or other organs. Anti-PCNA antibody has a high specificity but very low sensitivity for SLE, the positive rate is only 3%, which is rarely seen in other diseases. Anti-SS-A antibody is associated with various autoimmune diseases, most commonly in Sjogren's syndrome (40-80%), systemic lupus erythematosus (30-40%), primary biliary cirrhosis (20%), rheumatoid arthritis (3-5%), and occasionally in chronic active hepatitis. It will 100%happen in newborns with lupus erythematosus. Anti-Ro52 antibody is found in serum of patients with various autoimmune diseases, such as Sjogren's syndrome, systemic lupus erythematosus, dermatomyositis, etc. Anti-SS-B antibody is almost exclusively found in women with Sjogren's syndrome (40-80%) and SLE (10-20%), with a male-to-female ratio of 1:29. Anti-SS-A and anti-SS-B are often present together in Sjogren's syndrome. Anti-Scl-70 is a specific marker in patients with scleroderma (specificity is 98-100%). In patients with Progressive Systemic Sclerosis (PSS), the positive detection rate is 40-60%; in patients with Systemic Sclerosis, the positive detection rate is 20-40%. The presence of anti-Scl-70 is often associated with diffuse skin involvement and pulmonary fibrosis. Anti-PM-Scl is mainly found in patients with polymyositis and dermatomyositis, with a positive rate of 50-70%, it can also be found in patients overlapping with scleroderma (a positive rate of 50-70%). Anti-Jo-1 is commonly found in 25-35% patients with polymyositis (PM), 25% in PM/DM and less than 10% in DM alone. High titer of anti-nRNP/Sm (mainly U1-RNP) is a marker of mixed connective tissue disease (MCTD), with a positive rate of 95-100%. Its titer is associated with disease activity. It can also be detected in some patients with SLE, always accompanied by anti-SM. Anti-CENP-B is associated with progressive systemic sclerosis and primary biliary cirrhosis (PBC) (positive rates of 80-95%), and is particularly important for the diagnosis of CREST subtype in systemic scleroses (i.e., calcification, Raynaud's syndrome, esophageal motility disorders, stiff fingers, and telangiectasia). Anti-CENP-B is also detected in the serum of Raynold syndrome, tumors, and other rheumatic diseases, such as SLE, Sgregren's syndrome or rheumatoid arthritis. AMA-M2 is highly specific for primary biliary cirrhosis (PBC) and is detectable in approximately 90% of PBC patients, independent of disease activity. Low titer of AMA-M2 is seen in other chronic liver diseases (30%) and progressive systemic sclerosis (7-25%). Single chain DNA (ssDNA) is degenerated from double stranded DNA (dsDNA), and its antibody (anti-ssDNA) can be found in some autoimmune diseases and some infectious diseases. Anti-ssDNA antibody is another type of anti-DNA antibody, which is more sensitive to the diagnosis of early active SLE than anti-dsDNA antibody.

Antinuclear Antibody(ANA) Test Kit

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