Assess For Sjögren's Syndrome With Our Factory-Made ASS Test Kit

Chemiluminescent Solution（Autoimmune Diseases）
Series	Product Name	Abbr
Anti-Sjögren's Syndrome	α-Fodrin	α-Fodrin
	Anti-Sjögren's Syndrome Antigen A Antibody	SS-A
	Anti-Sjögren's Syndrome Antigen B Antibody	SS-B/La

Sjogren's syndrome (SS) is a chronic autoimmune disease that invades exocrine glands, especially salivary and lacrimal glands. The main manifestations are dry mouth and eyes, but also multiple organs and multiple system damage. A large number of lymphocytes infiltrated in the affected organs, and a variety of autoantibodies were positive in the serum. This syndrome is also known as autoimmune exocrine gland disease, Sjogren's syndrome, and oro-ocular Sjogren's arthritis syndrome. It often overlaps with other rheumatic or autoimmune diseases. Fifty to sixty percent of patients are positive for anti-SSA antibodies and/or anti-SSB antibodies. Rheumatoid factor is positive in more than half of patients. About 33% of patients are positive for antithyroid and antismooth muscle antibodies. All patients with positive antithyroid antibodies have positive antiparietal cell antibodies. Anti-salivary duct antibodies are present in about half of patients. About 10% of patients are positive for lupus cells. In recent years, it has been found that there are precipitated antibodies to soluble nucleic acid antigens in lymphoid cell exudates. Tuberculin and dinitrochlorobenzene skin tests, lymphocyte transformation tests, all suggest cellular immune dysfunction. SS-A/60-kD antibody positive patients appear in patients with systemic lupus erythematosus, the possibility of lupus is 80%, more likely to develop cutaneous lupus and concurrent nephritis, rarely appear alone in patients with primary Sjogren's syndrome. At present, the study data suggest that the positive rate of anti-SS-A antibody mainly refers to the presence of anti-native SS-A (60-kD protein) antibody. It has been found that the positive rate of anti-SS-A antibody in patients with primary Sjogren's syndrome (SS) is as high as 60% ~ 70%. Therefore, the European Organization for the Study of SS Diagnostic Criteria includes anti-SS-A antibody in the diagnostic criteria of SS. However, the specificity of this SS-A/60 kD antibody is poor, with a positive rate of 40% ~ 50% in SLE, and anti-SS-A antibodies can also be detected in RA, PSS, polymyositis or primary biliary sclerosis as well as a small number of normal subjects. The antigen corresponding to SS-B/La is RNA-protein complex, and its molecular weights are three peptides with molecular weights of 48 KD, 46 KD, and 45 KD, of which 46 KD has specificity, and anti-SS-A antibody and anti-SS-B/La antibody coexist in SS, the former has strong sensitivity and the latter has high specificity. Simultaneous detection of both can improve the diagnostic yield of SS. The diseases with high antibody positive rate include Sjogren's syndrome, neonatal lupus syndrome with congenital heart block, and the positive rate for Sjogren's syndrome is about 40%. Research shows that α- Fodrin antibody is closely related to the pathogenesis of SS. It may be a positive antibody in the early stage of SS. The specificity of SS is high. It can be used as an auxiliary diagnostic index for SS.

Anti-Sjögren's Syndrome(ASS) Test Kit

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