Factory Direct Other Anticoagulant Test Kit

Coagulation Solution
Series	Product Name	Abbr
Other Anticoagulant Tests	Lupus Anticoagulant Screening	LA Screening
	Lupus Anticoagulant Confirm	LA Confirm
	Antithrombin III	ATIII

Lupus anticoagulant is an autoantibody against negatively charged phospholipids, a type of antiphospholipid antibody, commonly found in patients with connective tissue diseases such as systemic lupus erythematosus. Because it was first studied in patients with lupus erythematosus, it was named lupus anticoagulant. It has been found to be present in a variety of diseases. The persistence of lupus anticoagulant substances is considered to be a red flag for unexplained recurrent miscarriage, stillbirth, fetal growth retardation, arteriovenous thrombosis, various thrombophilic diseases, and certain autoimmune diseases.Lupus anticoagulant (LAC) is an immunoglobulin, mostly IgG, a few IgM or a mixture of the two. Its immune activity mainly exists in IgM, and it is an antiphospholipid antibody (including anticardiolipin When prothrombin is converted into thrombin, it needs to contain prothrombin activator composed of phospholipids, coagulation factors V, X, Ca2+, etc., and LAC is for complex Among the phospholipids, it binds to phospholipids and inactivates the phospholipids, prolonging the conversion of prothrombin into thrombin. Therefore, it may be more appropriate to call it anti-prothrombin antibody, and the experimental detection of lupus anticoagulant substances may be more appropriate. The diagnosis of diseases in various clinical departments is of great significance Antithrombin III (antithrombin, AT III) is one of the most important anticoagulant substances in the human body. It is a glycoprotein with a relative molecular weight of about 58.2kD secreted by hepatocytes, and it is a serine protease inhibitor. By inhibiting the activity of thrombin and activated coagulation factor VIIa, IX, X, XI and XII serine proteases, it maintains the balance of blood coagulation in the body, and its role accounts for about 70% of the total activity of the anticoagulation system. Heparin can induce a conformational change in antithrombin, making it easier for thrombin to bind, which can greatly enhance the anticoagulant effect of antithrombin. Acquired AT deficiency is a common cause of venous thrombosis and pulmonary embolism Hereditary AT deficiency is an autosomal dominant genetic disease, the prevalence of this disease is about 1/5000, the incidence is mostly 10-25 years old, and patients often develop veins after surgery, trauma, infection, pregnancy or postpartum. Thrombosis, which can recur Increased AT III activity is seen in acute bleeding periods such as hemophilia, leukemia, and aplastic anemia, as well as in the treatment of oral anticoagulants. In anticoagulation therapy, if resistance to heparin therapy is suspected, AT III activity detection can be used to determine. AT III testing should also be preferred for monitoring during antithrombin replacement therapy and monitoring of anticoagulant effect of heparin.

Other Anticoagulant Test Kit, C-Luminary Biotechnology

Products Details

Featured Products

Contact us