Immunoglobulin Chemiluminescense Immunoassay Kit

Autoimmune hepatitis (AIH) is a rare chronic disease characterized by high levels of transaminase and immunoglobulin G (IgG). The presence of autoantibodies and histologically interfacial hepatitis, will affect body health of adults and children. AIH is usually acute and severe in childhood cases.
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Chemiluminescent Solution（Autoimmune Diseases）

Series

Product Name

Abbr

Immunoglobulin

Immunoglobulin G1

IgG1

Immunoglobulin G2

IgG2

Immunoglobulin G3

IgG3

Immunoglobulin G4

IgG4
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease, characterized by the elevation of aminotransferases, presence of anti-nuclear antibody or anti-smooth muscle antibody, elevated immunoglobulin G (IgG), and interface hepatitis/plasma-lymphocytic inflammation based on histology. Recent epidemiological studies have indicated an increasing trend in the prevalence of AIH worldwide, especially in male patients; this trend may suggest the alteration of environmental triggers of disease onset over time. As no disease-specific biomarker or histological finding is currently available, AIH requires a clinical diagnosis, and a validated diagnostic scoring system with acceptable specificity and sensitivity has been proposed. Regarding treatment, corticosteroids and azathioprine are recommended, and in those who exhibit an incomplete response or those who are intolerant to these drugs, second-line therapy, such as mycophenolate mofetil, is considered. Overall, the long-term outcome is excellent in patients with complete biochemical responses, while life-long maintenance treatment may be required since the cessation of immunosuppressive agents frequently leads to the relapse of the disease. Acute-onset AIH does occur, and the diagnosis is very challenging due to the lack of serum autoantibodies or elevated IgG. The unmet needs include earlier diagnosis, intervention with disseminated clinical practice guidelines, and recognition and improvement of patients' health-related quality of life with the development of novel corticosteroid-free treatment regimens. Immunoglobulin G is the highest content of immunoglobulin in serum, accounting for 75-80% of the total amount. In healthy people, IgG can be divided into four subtypes: IgG1-IgG4, in which IgG4 is rarely expressed and only accounts for 1-7%. Its low affinity for target antigen cannot activate complement, but can inhibit the formation of immune complexes of other subtypes.  

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